San Antonio, Florida, although reasonably distanced from the coast (about 25 miles inland), is not entirely exempt from hurricane threats. The town's relative proximity to both the Gulf and Atlantic coasts means hurricanes or strong tropical storms can bring high winds, heavy rainfall, and occasional tornadoes to the area. While the town's elevation, ranging from 75 to 180 feet above sea level, does offer some protection against direct storm surge impacts, heavy rainfall can lead to flash floods, especially if the storm is slow-moving. The region's generally flat topography means that water can accumulate quickly. Also, San Antonio's lack of significant flood control infrastructure increases its vulnerability to such events.

Over the last 30 years, several hurricanes and tropical storms have affected the San Antonio area. The most significant of these was likely Hurricane Irma in 2017, which produced extensive flooding and caused considerable damage in Pasco County. Prior to Irma, Tropical Storm Debby in 2012 brought heavy rainfall, leading to substantial flood impacts. The town has been generally fortunate to avoid direct hits from the most severe hurricanes, but as climate change potentially fuels more intense and frequent tropical cyclones, it is likely that the threat level for San Antonio will increase. It's essential for residents and officials to remain vigilant, stay updated with the latest forecasts during hurricane season, and have disaster plans and supplies ready.